Mechanisms Underlying Skeletal Muscle Weakness in Human Heart Failure
نویسندگان
چکیده
منابع مشابه
Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.
BACKGROUND Patients with chronic heart failure (HF) frequently experience skeletal muscle weakness that limits physical function. The mechanisms underlying muscle weakness, however, have not been clearly defined. METHODS AND RESULTS This study examined the hypothesis that HF promotes a loss of myosin protein from single skeletal muscle fibers, which in turn reduces contractile performance. Te...
متن کاملMolecular mechanisms underlying skeletal muscle weakness in human cancer: reduced myosin-actin cross-bridge formation and kinetics.
Many patients with cancer experience physical disability following diagnosis, although little is known about the mechanisms underlying these functional deficits. To characterize skeletal muscle adaptations to cancer in humans, we evaluated skeletal muscle structure and contractile function at the molecular, cellular, whole-muscle, and whole-body level in 11 patients with cancer (5 cachectic, 6 ...
متن کاملMechanisms Underlying Changes in Function of Aging Skeletal Muscle
Muscle wasting is a hallmark of the aging process in many species, including humans. The functional consequences of this loss of muscle mass include weakness, decreased physical function, and decreased ability to perform activities of daily living (ie, loss of independence). The ability to sustain muscle activity for a prolonged period (muscle endurance or fatigue-resistance) is a less well-rec...
متن کاملMechanisms underlying Andersen's syndrome pathology in skeletal muscle are revealed in human myotubes.
Andersen's syndrome is a rare disorder that has been defined with a triad: periodic paralysis, cardiac arrhythmia, and development anomalies. Muscle weakness has been reported in two-thirds of the patients. KCNJ2 remains the only gene linked to Andersen's syndrome; this gene encodes for the alpha-subunit of the strong inward-rectifier K+ channel Kir2.1. Several studies have shown that Andersen'...
متن کاملChronic heart failure reduces Akt phosphorylation in human skeletal muscle: relationship to muscle size and function.
Patients with chronic heart failure (HF) frequently lose muscle mass and function during the course of the disease. A reduction in anabolic stimuli to the muscle has been put forth as a potential mechanism underlying these alterations. The present study examined the hypothesis that skeletal muscle tissue from HF patients would show reduced IGF-1 expression and phosphorylation of signaling molec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation: Heart Failure
سال: 2009
ISSN: 1941-3289,1941-3297
DOI: 10.1161/circheartfailure.109.876433